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Kodak Workshop

Translational Applications of Optical/Multi-Modal In Vivo Molecular Imaging
Thursday, August 31, 2006 / 12:00 - 2:15 p.m.
Kona 4 Ballroom
Including Lunch for Participants of the Workshop

Join us for our first workshop on Translational Applications of Optical/Multi-Modal In Vivo Molecular Imaging. Enjoy a traditional Hawaiian lunch with a distinguished panel of scientific and medical experts who will present new, exciting information, and developments on a range of molecular imaging topics.

Select the following link to register for this workshop: https://www.123signup.com/register?id=qmsyb
(Please register for only ONE of the workshops on Thursday as the three are being held at the same time.)

Lunch - Welcome/Opening Remarks
Shahram Hejazi, Ph.D., WW General Manager, Molecular Imaging Systems, Kodak Health Group & Bill McLaughlin, Director of R&D, Molecular Imaging Systems, Kodak Health Group

Opto-Nuclear and Opto-MR Molecular Imaging
Juri Gelovani, MD, Ph.D., Professor & Chairman, The Department of Experimental Diagnostic Imaging, The University of Texas M.D. Anderson Cancer Center

Optical Imaging in Drug Discovery and Development -- From In vitro to In vivo
Xiaoyou Ying, Ph.D., Lead Research Investigator and Head of Bioimaging, Pathology/DSE Projects (US), DSE, Sanofi-Aventis
Abstract: Optical imaging possesses the unique advantages, such as safe-to-use, easy-to-apply, high specificity/sensitivity, and natively bridging in vitro molecular/cell studies to in vivo applications. This presentation will give an overview on optical imaging in drug discovery and development - from in vitro high-content-analysis to high-resolution optical sectioning, from intravital microscopy to in vivo macro-imaging. The pros/cons and applications of major in vivo optical imaging methods will be discussed. Various specific bio-optical methods and emerging techniques/applications will also be briefly discussed. The value of optical imaging in drug discovery and development will be highlighted with application samples.

Spectral Imaging: New Opportunities for Advanced Classification of Fluorescence Molecules
J. Paul Robinson, Ph.D., Director, Purdue University Cytometry Laboratories, Professor of Immunopharmacology, Professor of Biomedical Engineering

Multimodal Imaging in Mouse Tumor Models
Bohumil Bednar, Ph.D., Senior Investigator, Merck Research Laboratories
Abstract: Optical molecular imaging has become a prominent technology in the development of biomarkers for tumor growth in mouse tumor models. Here we report the development of imaging biomarkers in mouse metastatic tumor models based on rat mammary adenocarcinoma cells MATBIII with the genetically encoded optical probe luciferase. Development of metastatic lesions was followed using functional optical bioluminescence 2D and 3D imaging and anatomical imaging by MRI and CT. Some experiments were also done in parallel using PET system. The measurements demonstrated a good agreement between the optical bioluminescent biomarker of tumor growth used in pre-clinical testing and clinically available biomarkers defined by MRI, CT, and PET.

Optical Imaging: from Bench to Bedside
Professor, Dr. of Medicine, Christoph Bremer, Institut für Klinische Radiologie, Universitätsklinikum Münster
Abstract: Optical signals (fluorescence, bioluminescence) can be explored for non invasive detection of protein and gene expression in vivo. In the ‘diagnostic window’ (near infrared spectrum; NIR) the tissue penetration of light is considerable allowing to obtain optical information from sub-surface body structures. Moreover, since autofluorescence in the NIR is minimal high contrast to noise yields can be achieved resulting in a high sensitivity of the optical method for tracer detection (nanomolar range). A variety of optical tracers have been developed for non invasive imaging of protein expression. Affinity ligands (e.g. antibodies, antibody fragments, peptides) linked to NIR dyes can help to visualize various targets of interest such as cell receptors (e.g. EGF receptor) or makers of angiogenesis (e.g.: avß3-integrin). Autoquenched ‘smart’ probes can sensitively detect protease expression in vivo. Parallel to these tracer developments the technical ability to detect fluorescent signatures in vivo has made significant advances over the last years. Besides planar imaging techniques such as fluorescence reflectance imaging (FRI) new 3-dimensional, quantitative modalities such as fluorescence mediated tomography have been proposed and are constantly refined. New FMT algorithms now allow e.g. 3-D data acquisition in a non-touch technique. New tracers combined with technical advances such as FMT are powerful tools for interrogating molecular strucutures in vivo.

The Chemistry of Bioactivated MR Contrast Agents
Thomas J. Meade, Eileen M. Foell Professor, Departments of Chemistry; Biochemistry,and Molecular and Cell Biology; Neurobiology and Physiology; Radiology, Northwestern University
Abstract: Fundamental biological and clinical questions have driven technological advances in biological molecular imaging. The direct observation of ongoing developmental events in living embryos and the descendants of individual precursors in an intact embryo can be labeled by microinjection of a stable, nontoxic, MR lineage tracers. Since a complete time-series of high-resolution three-dimensional MR images can be analyzed forward or backward in time, it is possible to reconstruct the cell divisions and cell movements responsible for any particular descendant(s). In order to understand the mechanisms of gene expression in whole animals, we have developed a library of multimodal MR probes that are biochemically activated in-vivo. The lanthanide chelates modulate fast water exchange with the paramagnetic center, yielding distinct relaxivity states. The modulation is triggered by two types of events: i. enzymatic processing of the agent and, ii. the reversible binding of an intracellular messengers such as Zn(II) and Ca(II).

Optical/Multi-Modal In Vivo Imaging/Wrap-Up
Shahram Hejazi, Ph.D.

Kodak Molecular Imaging Systems
www.kodak.com/go/molecular

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